Paving the way for phage therapy using novel drug delivery approaches
Bacterial resistance against antibiotics is an emergent medical issue. The development of novel therapeutic
approaches is urgently needed and, in this context, bacteriophages represent a promising strategy to fight multi
resistant bacteria. However, for some applications, bacteriophages cannot be used without an appropriate drug
delivery system which increases their stability or provides an adequate targeting to the site of infection. This
review summarizes the main application routes for bacteriophages and presents the new delivery approaches
designed to increase phage’s activity. Clinical successes of these formulations are also highlighted. Globally, this
work paves the way for the design and optimization of nano and micro delivery systems for phage therapy.