thèse de Romain Bricca

Daptomycin is validated as a treatment of bone and joint infections (BJI) by the Infectious Disease Society of America. Dosage adaptation is currently exclusively adapted on the weight and the creatinine clearance. However, other factors such as sex and P-glycoprotein polymorphism, encoded by ABCB1 gene, may also greatly influence the pharmacokinetics. Between 2013 and 2016, all patients follow in French