Daptomycin does not have approval for the treatment of bone and joint infections (BJI). The Infectious Diseases Society of America guidelines propose daptomycin 6 mg/kg/d as alternative therapy for prosthetic joint infection, whereas recent data support the use of higher doses in these patients. Between 2010 and 2013, consecutive patients receiving daptomycin >6 mg/kg/d for complex BJI were included in
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