CRIOAc Lyon has published numerous BJI case reports in international medical journals. Lessons are learned with the treatment of every single patient. This knowledge gained by experience is valuable in the development of management algorithms and in the evaluation of medical and surgical strategies.

2023

Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
Front Med (Lausanne). 2023; 10: 1224922.
free access
Among carbapenem-resistant Enterobacterales, metallo-beta-lactamase producing strains represent a growing therapeutic challenge. While the association of aztreonam and ceftazidime-avibactam has been investigated in recent years for the treatment of infections involving these strains, little to no clinical data support the use of this association for the treatment of bone and joint infections. We report two cases of complex bone and joint

2022

Prosthetic Knee Joint Infection Due to Candida lusitaniae: A Diagnostic and Therapeutic Odyssey: A Case Study
Diagnostics (Basel). 2022 Oct 31;12(11):2640. doi: 10.3390/diagnostics12112640. PMID: 36359483
free access international
Prosthetic joint infections (PJIs) caused by fungi, although relatively rare, represent a major surgery-related complication. An extremely rare fungal PJI, following revised total knee replacement (TKR) caused by Candida lusitaniae, is reported, and a meticulous review of similar cases is provided. A 74-year-old female, who underwent primary total knee arthroplasty 10 years ago and a revision surgery three weeks ago,

2021

Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin‑rifampin treatment and complex reconstruction were needed for the cure
Arthroplasty (2021) 3:43 https://doi.org/10.1186/s42836-021-00097-1
free access international
Background: Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii, a strictly intracellular pathogen that can cause acute and chronic infection. Chronic Q fever can occur in immunocompetent as well as in immunocompromised hosts, as a persistent localized infection. The main localizations are endocardial, vascular and, less frequently, osteoarticular. The most frequent osteoarticular form is spondyliscitis. Recommended
Arthroscopic “Debridement Antibiotics and Implant Retention” With Local Injection of Personalized Phage Therapy to Salvage a Relapsing Pseudomonas Aeruginosa Prosthetic Knee Infection
Front Med (Lausanne). 2021 May 5;8:569159. doi: 10.3389/fmed.2021.569159. eCollection 2021.
international
Bacteriophages are viruses that specifically target bacteria. They are considered to have a high potential in patients with prosthetic joint infection (PJI), as they have a synergistic anti-biofilm activity with antibiotics. We report here the case of an 88-year-old man (63 kg) with relapsing Pseudomonas aeruginosa prosthetic knee infection. The patient had severe alteration of the general status and was bedridden with

2020

The Potential Innovative Use of Bacteriophages Within the DAC ® Hydrogel to Treat Patients With Knee Megaprosthesis Infection Requiring “Debridement Antibiotics and Implant Retention” and Soft Tissue Coverage as Salvage Therapy
Front Med (Lausanne). 2020 Jul 31;7:342. doi: 10.3389/fmed.2020.00342. eCollection 2020.
free access international
Infection is the most dramatic complication in patients with knee megaprosthesis. Its management is more complex in comparison with patients with primary arthroplasty, with a high risk of relapse. Lytic bacteriophages are considered to have a high potential in patients with prosthetic joint infection as it has been demonstrated that they have a synergistic anti-biofilm activity with antibiotics. The Defensive

2019

2018

2017

Intercalary diaphyseal endoprosthetic reconstruction for tibial septic non-union in an elderly patient: A case report
Orthop Traumatol Surg Res. 2017 Dec;103(8):1217-1220. doi: 10.1016/j.otsr.2017.09.011. Epub 2017 Sep 29.
free access international
The surgical treatment of septic non-union is challenging and carries a high failure rate. Bone defect management and fracture site stabilisation are key treatment objectives. We report the case of a 75-year-old woman who underwent intercalary endoprosthetic reconstruction of a large tibial defect due to septic non-union after two previous treatment failures. The two-stage procedure involved extensive excision of infected

2016

Three-step sequential management for knee arthroplasty after severe ballistic injury: Two cases
Orthop Traumatol Surg Res. 2016 Feb;102(1):131-4. doi: 10.1016/j.otsr.2015.08.014. Epub 2016 Jan 7.
free access international
Management of knee bone loss after gunshot trauma requires a multidisciplinary approach. Two cases of knee arthroplasty after devastating ballistic trauma are reported. Treatment comprised several steps: sampling, bone resection, reinforced cement spacer, latent sepsis control, and prosthetic reconstruction. The patients showed no neurovascular disorder and had a functioning extensor mechanism. At follow-up of at least 2 years, results were

2015

2014

Culture-negative Prosthetic Joint Arthritis Related to Coxiella Burnetii
Am J Med . 2014 Aug;127(8):786.e7-786.e10. doi: 10.1016/j.amjmed.2014.03.013. Epub 2014 Mar 22.
international
Background: The number of hip and knee arthroplasty procedures is steadily increasing as life expectancy increases. Coxiella burnetii may be responsible for culture-negative prosthetic joint arthritis and is associated with antibiotic failure and repeated surgeries. We report the first case series of C. burnetii-related culture-negative prosthetic joint arthritis. Methods: Cases were retrieved from the French National Referral center for Q