Lyon BJI Study Group

2022

Publications

• Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period
• Osteocutaneous-flap-related osteomyelitis following mandibular reconstruction: a cohort study of an emerging and complex bone infection
• Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period
• Implementation of a complex bone and joint infection phage therapy centre in France: lessons to be learned after 4 years’ experience

2021

Publications

• Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection
• Arthroscopic “Debridement and Implant Retention” With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection
• Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study
• Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection

Cas cliniques

• Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin‑rifampin treatment and complex reconstruction were needed for the cure
• Arthroscopic “Debridement Antibiotics and Implant Retention” With Local Injection of Personalized Phage Therapy to Salvage a Relapsing Pseudomonas Aeruginosa Prosthetic Knee Infection

Posters

• CEFTAROLINE AND CEFTOBIPROLE: REAL LIFE OFF LABEL USE IN PATIENTS WITH BJI OF THESE TWO BETALACTAMS ACTIVE AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCI
• IMPLEMENTATION OF A PHAGE THERAPY CENTER IN FRANCE DEDICATED TO COMPLEX BONE AND JOINT INFECTION: 4-YEAR EXPERIENCE OF MULTIDISCIPLINARITY AND MULTISTEP INTERACTIONS
• Coût des antibiothérapies hors AMM dans les infections ostéo-articulaires : Etude prospective observationnelle sur 6 ans dans un Centre de Référence pour la prise en charge des IOA complexes (CRIOAc)

2020

Publications

• Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference
• Anemia before reimplantation surgery : An overlooked modifiable risk factor of septic revision knee arthroplasty failure
• Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection
• Pseudomonas aeruginosa Implant-Associated Bone and Joint Infections: Experience in a Regional Reference Center in France
• Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach
• Tolerance and Microbiological Efficacy of Cefepime or piperacillin/tazobactam in Combination With Vancomycin as Empirical Antimicrobial Therapy of Prosthetic Joint Infection: A Propensity-Matched Cohort Study
• Phagothérapie pour les patients présentant une infection ostéoarticulaire : historique, fondements, faisabilité et perspectives en France

Communications orales

• Osteomyelitis following mandibular reconstruction with free fibula flap : a cohort study of an emerging and complex bone and joint infection

Cas cliniques

• The Potential Innovative Use of Bacteriophages Within the DAC ® Hydrogel to Treat Patients With Knee Megaprosthesis Infection Requiring “Debridement Antibiotics and Implant Retention” and Soft Tissue Coverage as Salvage Therapy

2019

Posters

• Tolerance and microbiological efficacy cefepim or piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of PJI
• Denosumab related osteonecrosis of the jaw: an emergent and potentially complex bone and joint infection
• Comparison of tolerance and microbiological efficacy of cefepim and piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of prosthetic joint infection: a propensity-matched cohort study
• Assessment of drug adherence to oral antibacterial therapy in bone and joint infections: a pilot study
• Observance au traitement antibiotique par voie orale dans les infections ostéo-articulaires : étude pilote
• Economic study of medico-surgical strategies in patients with chronic knee or hip prosthetic joint infection
• Purified personalized bacteriophages as part of salvage therapy in patients with complex BJI: A 2-year experience in a reference center in France
• Impact on the gut microbiota of the prolonged antimicrobial therapy in patients with bone and joint infection (BJI): results from the OSIRIS prospective study in France
• Purified personalized bacteriophages as part of salvage therapy in patients with complex BJI: A 2-year experience in a reference center in France
• Denosumab related osteonecrosis of the jaw: an emergent and potentially complex bone and joint infection

Cas cliniques

• Plasma cell infiltration in a 28-year-old patient with chronic indolent fracture-related tibial infection due to Cutibacterium acnes

Publications

• Subcutaneous suppressive antibiotic therapy for bone and joint infections: safety and outcome in a cohort of 10 patients
• Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study

2018

Publications

• Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?
• Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy
• Innovations for the treatment of a complex bone and joint infection due to XDR Pseudomonas aeruginosa including local application of a selected cocktail of bacteriophages
• Population pharmacokinetics and probability of target attainment of ertapenem administered by subcutaneous or intravenous route in patients with bone and joint infection
• Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?

Posters

• Capacité du linézolide et du tédizolide à éradiquer Staphylococcus aureus en intracellulaire et sous forme de biofilm au cours du traitement des infections ostéo-articulaires
• Traitement des infections ostéo-articulaires à S. aureus : activité intra-ostéoblastiques des rifamycines et impact sur l’émergence intracellulaire de small colony variants
• Infections chroniques sur prothèses articulaires (IPA) à Cutibacterium acnes diagnostiquées par PCR spécifique : une étude descriptive de 6 patients
• Salvage ‘DAIR’ (debridement, antibiotics and implant retention) with local injection of a selected mix of bacteriophages in an elderly patient with relapsing S. aureus prosthetic-joint infection

Cas cliniques

• Pott’s disease associated with large and multiple abscesses in a 30-year-old migrant from Chad
• Correction of Linezolid-Induced Myelotoxicity After Switch to Tedizolid in a Patient Requiring Suppressive Antimicrobial Therapy for Multidrug-Resistant Staphylococcus epidermidis Prosthetic-Joint Infection
• Chronic and severe prosthetic joint infection complicated by amyloid A amyloidosis with renal and bladder impairment

2017

Posters

• Selection and local application of a cocktail of bacteriophages in addition with local colistin therapy and off-label use of ceftolozane/tazobactam for the treatment of a complex bone and joint infection due to multidrug-resistant P. aeruginosa
• Cost of off-label antibiotic therapy in bone and joint infection (BJI) : prospective 2-year study in a complex BJI reference center
• Microbiological epidemiology in patients experiencing microbiological or clinical failure following reimplantation after a 2-stage exchange strategy for hip or knee prosthetic joint infection (PJI)
• Pressure ulcer-related pelvic osteomyelitis : Evaluation of a two-stage surgical strategy (debridement, negative pressure therapy and flap coverage) with prolonged antimicrobial therapy
• Microbiological epidemiology depending on time to occurrence of prosthetic joint infection (PJI) : impact on the empirical antimicrobial strategies
• Corynebacterium bone and joint infection (BJI): A retrospective cohort from a BJI reference center
• Subcutaneous Suppressive Antibiotic Therapy for Bone and Joints Infections: Safety and Outcome in a Cohort of 10 Patients

Cas cliniques

• Ethmoiditis with subperiosteal and retro-ocular abscesses due to Aeromonas sobria in a 16-year-old boy exposed to the Ardèche river
• Implant-associated ESBL- Klebsiella pneumonia producing small colony variant bone and joint infection in a healthy 40-year-old man
• Gentamicin-vancomycin-colistin local antibiotherapy in a cement spacer in a 54-year-old haemophilic patient with relapsing plurimicrobial severe prosthetic joint infection

2016

Posters

• Pharmacokinetics of Ertapenem Administered by Intravenous or Subcutaneous Route in Patients with Bone and Joint Infections: Population and Monte Carlo simulation study

Cas cliniques

• Mycobacterium bovis prosthetic joint infection
• Chronic tibial pandiaphysitis with Brodie abscess due to Salmonella saprophyticus in a 29-year-old healthy man

Publications

• Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis
• Diffuse Escherichia coli gaseous abscesses
• Pristinamycin in the treatment of MSSA bone and joint infection
• Teicoplanin-based antimicrobial therapy in Staphylococcus aureus bone and joint infection: tolerance, efficacy and experience with subcutaneous administration
• Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center

2015

Posters

• Autologous Bone Flap infection Following Craniectiomy: Clinical Experience in a Referral Center

Cas cliniques

• Reactivation of Clostridium tertium bone infection 30 years after the Iran-Iraq war
• Post-traumatic chronic bone and joint infection caused by Butyricimonas spp, and treated with high doses of ertapenem administered subcutaneously in a 30-year-old obese man
• Chronic enterococcal spinal implant infection 6 years after instrumentation of a severe scoliosis in a 22-year-old woman
• A 22-year-old woman with right lumpy jaw syndrome and fistula
• Metallosis-associated prosthetic joint infection

Publications

• Delta-toxin production deficiency in Staphylococcus aureus: a diagnostic marker of bone and joint infection chronicity linked with osteoblast invasion and biofilm formation
• Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis

2014

Publications

• Rapid detection of Staphylococcus aureus and methicillin resistance in bone and joint infection samples: evaluation of the GeneXpert MRSA/SA SSTI assay
• Determinants of methicillin-susceptible Staphylococcus aureus native bone and joint infection treatment failure: a retrospective cohort study.
• Antimicrobial-related Severe Adverse Events During Treatment of Bone and Joint Infection Due to Methicillin-Susceptible Staphylococcus Aureus
• Methicillin-susceptible Staphylococcus Aureus Clonal Complex 398: High Prevalence and Geographical Heterogeneity in Bone and Joint Infection and Nasal Carriage
• Activation of NK cells in patients with chronic bone and joint infection due to staphylococci expressing or Not the small colony variant phenotype.
• Risk factors, diagnosis and management of bone flap osteomyelitis following craniectomy