2023
Formation continue et webinaires
Cas cliniques
Communications orales
- Improving the diagnosis of BJI : evaluation of 16S rRNA targetes metagenomics from Oxford Nanopore Technologies
- Intra articular injection(s) of active bacteriophages as adjuvant therapy in patients with PJI qualified for open or arthroscopic DAIR followed by suppressive antimicrobial therapy (SAT)
- Exclusive medical treatment combining intraarticular injections of active bacteriophages as adjuvant therapy to antibiotics in patients with S. aureus complex PJI contraindicated for, or refusing, surgery
Posters
- MULTICENTRE EVALUATION OF RAPID MOLECULAR SYNDROMIC APPROACH IN JOINT INFECTIONS USING A NEW DEDICATED PANEL : FILMARRAY® BIOFIRE® JOINT INFECTION
- Validation of a rabbit model of in vivo biofilm formation on beads for ex vivo evaluation of the antibiofilm activity of antistaphylococcal drugs
2022
Communications orales
Publications
- Les virus au service de la santé : les bactériophages
- Phage Therapy against Staphylococcus aureus: Selection and Optimization of Production Protocols of Novel Broad-Spectrum Silviavirus Phages
- Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period
- Activity of Exebacase (CF-301) against Biofilms Formed by Staphylococcus epidermidis Strains Isolated from Prosthetic Joint Infections
- Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection
- Paving the way for phage therapy using novel drug delivery approaches
- Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period
- Novel strategies to diagnose prosthetic or native bone and joint infections
- Implementation of a complex bone and joint infection phage therapy centre in France: lessons to be learned after 4 years’ experience
- Prophylactic Antibiofilm Activity of Antibiotic-Loaded Bone Cements against Gram-Negative Bacteria
Diplôme Inter-Universitaire
2021
Publications
- Editorial: Innovative Approaches in the Management of Bone and Joint Infection.
- Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection
- Novel strategies to diagnose prosthetic or native bone and joint infections
- Evaluation of intraosteoblastic activity of dalbavancin against Staphylococcus aureus in an ex vivo model of bone cell infection
- Arthroscopic “Debridement and Implant Retention” With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection
- Lysosomal alkalization to potentiate eradication of intra-osteoblastic Staphylococcus aureus in the bone and joint infection setting.
- Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection
- Experience With the Use of the MicroDTTect Device for the Diagnosis of Low-Grade Chronic Prosthetic Joint Infections in a Routine Setting
- Impact on the Gut Microbiota of Intensive and Prolonged Antimicrobial Therapy in Patients With Bone and Joint Infection
- Antimicrobial activity of the new FabI inhibitor Afabicin desphosphono against intraosteoblastic Staphylococcus aureus
Ouvrages
Cas cliniques
- Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin‑rifampin treatment and complex reconstruction were needed for the cure
- Arthroscopic “Debridement Antibiotics and Implant Retention” With Local Injection of Personalized Phage Therapy to Salvage a Relapsing Pseudomonas Aeruginosa Prosthetic Knee Infection
Posters
- CEFTAROLINE AND CEFTOBIPROLE: REAL LIFE OFF LABEL USE IN PATIENTS WITH BJI OF THESE TWO BETALACTAMS ACTIVE AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCI
- IMPLEMENTATION OF A PHAGE THERAPY CENTER IN FRANCE DEDICATED TO COMPLEX BONE AND JOINT INFECTION: 4-YEAR EXPERIENCE OF MULTIDISCIPLINARITY AND MULTISTEP INTERACTIONS
- Projet PHAGEinLYON – Traitement par phagothérapie des infections ostéo-articulaires à staphylocoques: caractérisation de dix-sept bactériophages anti-Staphylococcus
- Mise en place d’un centre de phagothérapie en France dédié aux infections ostéo-articulaires complexes : 4 ans d’expérience de multidisciplinarité et d’interactions multi-étapes
- Implementation of a phage therapy center in France dedicated to complex bone and joint infection: 4-year experience of multidisciplinarity and multistep interactions
- Impact on the gut microbiota of intensive and prolonged antimicrobial therapy in patients with bone and joint infection
- Isolation and characterization of a novel Jumbo phage active against the emerging ST307 carbapenemase-producing K. pneumoniae clone
- Targeting coagulase negative staphylococci causing prosthetic infections with bacteriophages: can we use polyvalent anti Staphylococcus phages ?
- Phage discovery: isolation and characterization of seventeen novel anti-Staphylococcus aureus bacteriophages
Formation continue et webinaires
2020
Publications
- Antibiotics in Bone Cements Used for Prosthesis Fixation: An Efficient Way to Prevent Staphylococcus aureus and Staphylococcus epidermidis Prosthetic Joint Infection
- Bone and Joint Infection Involving Corynebacterium spp.: From Clinical Features to Pathophysiological Pathways
- Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection
- Pseudomonas aeruginosa Implant-Associated Bone and Joint Infections: Experience in a Regional Reference Center in France
- Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach
- Hematogenous osteomyelitis in childhood can relapse many years later into adulthood
- Tolerance and Microbiological Efficacy of Cefepime or piperacillin/tazobactam in Combination With Vancomycin as Empirical Antimicrobial Therapy of Prosthetic Joint Infection: A Propensity-Matched Cohort Study
- Phagothérapie pour les patients présentant une infection ostéoarticulaire : historique, fondements, faisabilité et perspectives en France
- Phage therapy in bone and joint infection: history, scientific basis, feasibility and perspectives in France.
- Efficacy of Bacteriophages in a Staphylococcus aureus Nondiabetic or Diabetic Foot Infection Murine Model
- Evaluation of the Activity of a Combination of Three Bacteriophages Alone or in Association with Antibiotics on Staphylococcus aureus Embedded in Biofilm or Internalized in Osteoblasts
- Antibiofilm and intraosteoblastic activities of rifamycins against Staphylococcus aureus: promising in vitro profile of rifabutin
Posters
- Utilité du dithiothréitol pour diagnostiquer les infections sur prothèses ostéo articulaires
- Personalized production and administration of bacteriophages: lessons learned from a unique European academic collaboration to treat a patient with pandrug-resistant spinal P. aeruginosa infection
- Intravenous administration of personalized cocktail of bacteriophages as salvage therapy in combination with ceftazidime/avibactam in patients with relapsing P. aeruginosa bacteremia associated with intravascular implants: Lesson to be learned from two cases
- Ultrasound-guided local administration of personalized cocktail of bacteriophages followed by suppressive antibiotherapy as salvage therapy in patients with relapsing total femur prosthetic joint infection (PJI)
- Arthroscopic Debridement Antibiotic And Implant Retention (DAIR) with local administration of Exebacase (Lysin CF-301) (LysinDAIR) followed by suppressive tedizolid as salvage therapy in elderly patients for relapsing multidrug-resistant Staphylococcus epidermidis prosthetic knee infection
Cas cliniques
2019
Posters
- Tolerance and microbiological efficacy cefepim or piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of PJI
- Denosumab related osteonecrosis of the jaw: an emergent and potentially complex bone and joint infection
- Comparison of tolerance and microbiological efficacy of cefepim and piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of prosthetic joint infection: a propensity-matched cohort study
- Infections ostéo-articulaire à S. aureus : activité intra-ostéoblastique et anti-biofilm des rifamycines
- L’alcalinisation phagolysosomale dans le traitement des infections ostéo-articulairesà Staphylococcus aureus
- Comparaison de deux modèles pharmacocinétiques pour le suivi thérapeutique de la daptomycine
- Evaluation de l’efficacité d’un assemblage de trois bactériophages anti staphylococcus contre les bactéries au sein du biofilm ou internalisées dans les ostéoblastes
- Effets anti-biofilm prophylactiques de ciments osseux chargés d’antibiotiques contre Staphylococcus aureus et Staphylococcus epidermidis
- Implementation and validation of a pharmacokinetic model for Bayesian therapeutic drug monitoring of daptomycin in patients with bone and joint infection
- Purified personalized bacteriophages as part of salvage therapy in patients with complex BJI: A 2-year experience in a reference center in France
- Impact on the gut microbiota of the prolonged antimicrobial therapy in patients with bone and joint infection (BJI): results from the OSIRIS prospective study in France
- Pseudomonas aeruginosa implant-associated Bone and Joint Infections : Experience in a Regional Reference Center in France
- Prophylactic anti-biofilm effects of antibiotic-loaded bone cements against Staphylococcus aureus and Staphylococcus epidermidis
- Evaluation of the efficacy of an assembly of three bacteriophages compared or associated to antibiotics on Staphylococcus aureus embedded in biofilms or internalised in osteoblasts
- Purified personalized bacteriophages as part of salvage therapy in patients with complex BJI: A 2-year experience in a reference center in France
- Denosumab related osteonecrosis of the jaw: an emergent and potentially complex bone and joint infection
Publications
- The CRIOAc healthcare network in France: A nationwide Health Ministry program to improve the management of bone and joint infection
- Subcutaneous suppressive antibiotic therapy for bone and joint infections: safety and outcome in a cohort of 10 patients
- Pubic osteomyelitis: Epidemiology and factors associated with treatment failure
- Interaction Between Staphylococcal Biofilm and Bone: How Does the Presence of Biofilm Promote Prosthesis Loosening?
- Evaluation of the ability of linezolid and tedizolid to eradicate intraosteoblastic and biofilm-embedded Staphylococcus aureus in the bone and joint infection setting
- Efficacy of bacteriophages in a S. aureus non-diabetic or diabetic foot infection murine model
- Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study
2018
Publications
- Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?
- Association between biofilm formation phenotype and clonal lineage in Staphylococcus aureus strains from bone and joint infections
- Innovations for the treatment of a complex bone and joint infection due to XDR Pseudomonas aeruginosa including local application of a selected cocktail of bacteriophages
- Prolonged Cefoxitin Infusion Using Mobile Elastomeric Infusors In Outpatients With Bone And Joint Infection
- Population pharmacokinetics and probability of target attainment of ertapenem administered by subcutaneous or intravenous route in patients with bone and joint infection
- Pressure ulcer-related pelvic osteomyelitis: evaluation of a two-stage surgical strategy (debridement, negative pressure therapy and flap coverage) with prolonged antimicrobial therapy
- Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?
Formation continue et webinaires
Diplôme Inter-Universitaire
- Physiopathologie des IOA
- Diagnostic microbiologique des Infections Ostéo-Articulaires : gestion des prélèvements et techniques
Posters
- Interventional Study of Bone and Joint Infections related gut Dysbiosis (OSIRIS study): first results of a prospective multicenter trial
- Activité de nouvelles molécules anti-staphylococciques sur la persistance intra-ostéoblastique
- Infection de prothèse et changement en 1 temps : prétraitement par antibiothérapie ciblée chez des patients à risque
- Capacité du linézolide et du tédizolide à éradiquer Staphylococcus aureus en intracellulaire et sous forme de biofilm au cours du traitement des infections ostéo-articulaires
- Traitement des infections ostéo-articulaires à S. aureus : activité intra-ostéoblastiques des rifamycines et impact sur l’émergence intracellulaire de small colony variants
- Evaluation de l’utilisation de la céfoxitine en association en administration parentérale continue dans le traitement des infections ostéo-articulaires
- Infections chroniques sur prothèses articulaires (IPA) à Cutibacterium acnes diagnostiquées par PCR spécifique : une étude descriptive de 6 patients
- Salvage ‘DAIR’ (debridement, antibiotics and implant retention) with local injection of a selected mix of bacteriophages in an elderly patient with relapsing S. aureus prosthetic-joint infection
- Infections ostéo-articulaires : activité intra-ostéoblastique des rifamycines et oxazolidinones
Cas cliniques
2017
Formation continue et webinaires
Thèses
Posters
- Selection and local application of a cocktail of bacteriophages in addition with local colistin therapy and off-label use of ceftolozane/tazobactam for the treatment of a complex bone and joint infection due to multidrug-resistant P. aeruginosa
- Microbiological epidemiology in patients experiencing microbiological or clinical failure following reimplantation after a 2-stage exchange strategy for hip or knee prosthetic joint infection (PJI)
- Pressure ulcer-related pelvic osteomyelitis : Evaluation of a two-stage surgical strategy (debridement, negative pressure therapy and flap coverage) with prolonged antimicrobial therapy
- Microbiological epidemiology depending on time to occurrence of prosthetic joint infection (PJI) : impact on the empirical antimicrobial strategies
- Pubic osteomyelitis (PO) : Epidemiology and factors associated with management failure in two French Reference Centers
- Corynebacterium bone and joint infection (BJI): A retrospective cohort from a BJI reference center
- Subcutaneous Suppressive Antibiotic Therapy for Bone and Joints Infections: Safety and Outcome in a Cohort of 10 Patients
Publications
- Salvage therapy for complex bone and joint infections with ceftaroline: a multicentre, observational study
- Intraosteoblastic activity of daptomycin in combination with oxacillin and ceftaroline against MSSA and MRSA
- Clinical metagenomics of bone and joint infections: a proof of concept study
2016
Posters
- Klebsiella pneumoniae réductrice de carbapenemases KPC : Activité bactéricide de six antibiotiques
- Adaptation of the capacity to form biofilm in Staphylococcus aureus isolates during the course of human chronic bone and joint infections
- Génériques du Méropénème et activité bactéricide sur souches KPC
- Investigation of the ability to be internalized in osteoblasts as a pathophysiological mechanism involved in Staphylococcus non-aureus bone and joint infection
- Pharmacokinetics of Ertapenem Administered by Intravenous or Subcutaneous Route in Patients with Bone and Joint Infections: Population and Monte Carlo simulation study
- Biofilm : Adaptation in vivo des souches de S. aureus responsables d’IOA
- Alere™ PBP2a SA Culture Colony Test : Evaluation de la nouvelle génération du test
Formation continue et webinaires
Communications orales
- Centre de Référence des Infections Ostéo-articulaires complexes (CRIOAc) : Structuration du soin et de la recherche aux HCL
- Intérêt réel du séquençage génomique en 2016
- Pathophysiology of staphylococcal bone and joint infections
- Interactions between staphylococci, osteoblasts and osteoclasts: What do we know in 2016?
Publications
- Infections ostéo-articulaires complexes : Le rôle des antibiotiques locaux
- Diagnostic des infections ostéo-articulaires
- Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis
- Adaptive processes of Staphylococcus aureus isolates during the progression from acute to chronic bone and joint infections in patients
- Pristinamycin in the treatment of MSSA bone and joint infection
- Teicoplanin-based antimicrobial therapy in Staphylococcus aureus bone and joint infection: tolerance, efficacy and experience with subcutaneous administration
- Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center
- Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections
- Pathophysiological Mechanisms of Staphylococcus Non-aureus Bone and Joint Infection: Interspecies Homogeneity and Specific Behavior of S. pseudintermedius
- Rapid bench identification of methicillin-sensitive and methicillin-resistant Staphylococcus aureus: A multicenter comparative evaluation of Alere PBP2a Culture Colony Test (Alere) Versus Slidex MRSA detection (bioMérieux)
- Preliminary results of a new antibiotic susceptibility test against biofilm installation in device-associated infections: the Antibiofilmogram®
Cas cliniques
2015
Formation continue et webinaires
Posters
- Evidence of adaptative processes of Staphylococcus aureus isolates in the course of chronic bone and joint infections in patients
- Management of P. acnes bone and joint infection in a regional reference centre in France
Cas cliniques
- Reactivation of Clostridium tertium bone infection 30 years after the Iran-Iraq war
- Post-traumatic chronic bone and joint infection caused by Butyricimonas spp, and treated with high doses of ertapenem administered subcutaneously in a 30-year-old obese man
- Metallosis-associated prosthetic joint infection
Publications
- Delta-toxin production deficiency in Staphylococcus aureus: a diagnostic marker of bone and joint infection chronicity linked with osteoblast invasion and biofilm formation
- Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis
- Dual impact of live Staphylococcus aureus on the osteoclast lineage, leading to increased bone resorption
2014
Publications
- Management strategies of prosthetic joint infections of the hip
- Rapid detection of Staphylococcus aureus and methicillin resistance in bone and joint infection samples: evaluation of the GeneXpert MRSA/SA SSTI assay
- Determinants of methicillin-susceptible Staphylococcus aureus native bone and joint infection treatment failure: a retrospective cohort study.
- Antimicrobial-related Severe Adverse Events During Treatment of Bone and Joint Infection Due to Methicillin-Susceptible Staphylococcus Aureus
- Methicillin-susceptible Staphylococcus Aureus Clonal Complex 398: High Prevalence and Geographical Heterogeneity in Bone and Joint Infection and Nasal Carriage
- Activation of NK cells in patients with chronic bone and joint infection due to staphylococci expressing or Not the small colony variant phenotype.
- Actinomycosis : etiology, clinical features, diagnosis, treatment and management
- Risk factors, diagnosis and management of bone flap osteomyelitis following craniectomy
Thèses
- Physiopathologie des infections ostéo-articulaires à Staphylococcus aureus
- Infections ostéo-articulaires à Staphylococcus aureus et Staphylococcus epidermidis : épidémiologie clinique et moléculaire, corrélation entre expression clinique et interaction staphylocoques – ostéoblastes