2024
Thèses
Communications orales
- Les Révisions De Prothèses Totales Du Genou en un ou deux temps sont une stratégie efficace pour traiter l’infection chronique périprothétique du genou. A propos de 218 RPTG septiques avec un suivi minimum de 24 mois.
- Multi-drug resistant pathogens in PJI: How phages could help in the era of multi-drug resistance
Posters
- CIERNY AND MADER STAGE III ADULT LONG BONE CHRONIC OSTEOMYELITIS: RETROSPECTIVE STUDY AT THE LYON REFERENCE CENTRE FOR COMPLEX OSTEOARTICULAR INFECTIONS (CRIOAC)
- TWO NEW LOCAL POTENTIAL WEAPONS AS ADJUVANT DURING DAIR STRATEGY IN CHRONIC PERIPROSTHETIC JOINT INFECTIONS (PJI): A SINGLE CENTER RETROSPECTIVE STUDY
- Utilisation du STIMULAN® et du BACTISURE® dans les infections chroniques d’implants articulaires : une série rétrospective monocentrique
Ouvrages
2023
Communications orales
- Treatment of PJI in centers – The French CRIOAc model
- Phage therapy to fight severe infections in the era of antimicrobial resistance
- CONSEIL SCIENTIFIQUE DES CRIOAC : LA COOPÉRATION, MOTEUR DE PROJET
- CRIOAc / National Data/ LHA experience
- Clinical experience with bacteriophage therapy in BJIs/PJIs: the Lyon perspective
- The public health and economic burden of bone and joint infections, improvement areas
- Nuevas modalidades de tratamiento (fagos) / New Treatment modalities (phage therapy)
- Bacteriophage therapy in BJI : Fact or fiction ? From mythology to clinical evidence
- How to set up a phage therapy center ?
- Intra articular injection(s) of active bacteriophages as adjuvant therapy in patients with PJI qualified for open or arthroscopic DAIR followed by suppressive antimicrobial therapy (SAT)
- Exclusive medical treatment combining intraarticular injections of active bacteriophages as adjuvant therapy to antibiotics in patients with S. aureus complex PJI contraindicated for, or refusing, surgery
Diplôme Inter-Universitaire
Publications
- Phage Therapy as a Novel Therapeutic for the Treatment of Bone and Joint Infections
- Phages and phage-borne enzymes as new antibacterial agents
- Diagnostic, clinical management and outcome of bone flap-related osteomyelitis following cranioplasty
- Restoring the Anatomy of Long Bones with Large Septic Non-Union Defects with the Masquelet Technique
- Daptomycin Exposure as a Risk Factor for Daptomycin-Induced Eosinophilic Pneumonia and Muscular Toxicity
- Case Studies and Literature Review of Francisella tularensis–Related Prosthetic Joint Infection
- Cost-effectiveness of a bone substitute delivering gentamicin in the treatment of chronic osteomyelitis of long bones: Protocol for the CONVICTION randomized multicenter study
Thèses
- Modélisation Pharmacocinétique et Pharmacodynamique de la daptomycine dans les infections ostéoarticulaires
- Ostéomyélite chronique des os longs de l’adulte de stade III selon Cierny et Mader : Etude rétrospective au Centre de Référence des Infections Ostéo-Articulaires complexes (CRIOAc) de Lyon
Formation continue et webinaires
- Labellisation DGOS 2023-2028 : un nouveau paysage
- Phagothérapie dans les IOA: protocole PhagoDAIR I
- Evaluation d’un substitut osseux à la gentamicine (CERAMENT-G™) dans le traitement de l’ostéomyélite chronique des os longs : étude CONVICTION
- Fonctionnement du comité scientifique des CRIOAc
- Implication du CRIOAc Lyon dans les missions en Arménie pour la gestion des blessés de guerre : retour d’expérience
- Innovative care in patents with PJI – What is your Treatment of choice ? PART 1
- Innovative care in patents with PJI – What is your Treatment of choice ? PART 2
- Innovative care in patents with PJI – What is your Treatment of choice ? PART 3
Cas cliniques
Posters
- Diagnostic, management and outcome of bone flap osteomyelitis following craniectomy: a cohort study
- Validation of a rabbit model of in vivo biofilm formation on beads for ex vivo evaluation of the antibiofilm activity of antistaphylococcal drugs
- Risk factors, management and outcome of early (<6 months) open fracture-related infections (FRI)
2022
Communications orales
- Phage therapy in bone infections
- Phagothérapie : Où en est-on en Europe et en France ?
- Phagothérapie dans différentes indications cliniques
- PLACE DES PHAGES EN 2022
- MANAGEMENT OF HIP AND KNEE PROSTHESIS JOINT INFECTION (PJI) DUE TO S. AUREUS BY THE « DEBRIDEMENT ANTIBIOTICS AND IMPLANT RETENTION » (DAIR) PROCEDURE IN FRENCH REFERENCE CENTERS (CRIOACS) IN 2019: A RETROSPECTIVE COHORT STUDY
- Bacteriophage therapy – Current clinical experience: the Lyon perspective
- SINGLE CENTER, EXPLORATORY, OPEN-LABEL PROSPECTIVE STUDY USING THE MINIMALLY INVASIVE LYSINDAIR PROCEDURE (ADMINISTRATION OF THE LYSIN CF-301 DURING THE PERFORMANCE OF AN ARTHROSCOPIC DAIR) IN PATIENTS WITH CHRONIC COAGULASE-NEGATIVE STAPHYLOCOCCI KNEE PJI WITH TWO DIFFERENT CLINICAL PRESENTATIONS AND TREATMENT PARADIGMS
- Retro-PJI : Etude de cohorte rétrospective multicentrique sur les infections de prothèse articulaire (IPA) de la hanche et du genou dues à Staphylococcus aureus dans neuf centres de référence des infections ostéoarticulaires complexes (CRIOAc) en France en 2019
- Evaluation d’un substitut osseux à la gentamicine (CERAMENT-G™) dans le traitement de l’ostéomyélite chronique des os longs
- Phagothérapie et IOA : Cas compassionnels et études cliniques dont PhagoDAIR
- Phages therapy: a substitute of antibiotics?
- Clinical evidence for the efficacy of phages (so far)
Publications
- Staphylococcus lugdunensis prosthetic joint infection: A multicentric cohort study
- Optimisation préopératoire afin de prévenir les infections de prothèses articulaires
- Les virus au service de la santé : les bactériophages
- Phage Therapy against Staphylococcus aureus: Selection and Optimization of Production Protocols of Novel Broad-Spectrum Silviavirus Phages
- Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period
- Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues
- Osteocutaneous-flap-related osteomyelitis following mandibular reconstruction: a cohort study of an emerging and complex bone infection
- Activity of Exebacase (CF-301) against Biofilms Formed by Staphylococcus epidermidis Strains Isolated from Prosthetic Joint Infections
- Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection
- Paving the way for phage therapy using novel drug delivery approaches
- Necrotizing external otitis: analysis of relapse risk factors in 66 patients managed during a 12 year period
- Novel strategies to diagnose prosthetic or native bone and joint infections
- Implementation of a complex bone and joint infection phage therapy centre in France: lessons to be learned after 4 years’ experience
- Prophylactic Antibiofilm Activity of Antibiotic-Loaded Bone Cements against Gram-Negative Bacteria
Diplôme Inter-Universitaire
- Présentation du DU et du réseau des centres de référence des IOA (CRIOAc network)
- Intérêt des bactériophages et des lysines de bactériophages au cours des infections ostéoarticulaires
- Innovation dans l’antibiothérapie locale
- Place de la recherche clinique dans le réseau des CRIOAc
- Traitement médical des ostéites/ostéomyélites
- Infections ostéo-articulaires et Phagothérapie
- Traitement des Infections à Staphylocoques
2021
Communications orales
- Bacilles à Gram négatif de résistance émergente aux antibiotiques : nouveaux antibiotiques et nouvelles stratégies thérapeutiques
- Place de la phagothérapie
- Diagnostic des infections de prothèse basés sur les biomarqueurs locaux et circulants
- The Phage lysinCF-301 (Exebacase) in patients with staphylococcal prosthetic joint infection: Experience of a referral clinical center
- In patients with BJI, 6 and 12 weeks of antimicrobial therapy seems to have a similar impact on the gut microbiota and no particular antibiotic seems to impact its recovery
- Conservative management of chronic infections: Experience with subcutaneous antimicrobial suppressive treatment and bacteriophages
- French Periprosthetic infection Network : Referral / Reference Centers for the management of BJI
- Goals and duties in a reference center for infections
- L’actualité en 3 patients : IOA complexe
- Actualités pharmaceutiques dans les infections ostéo-articulaires : antibiothérapie et phagothérapie
- Innovative Approach in Bone and Joint Infections: Bone Substitutes, Phages
- Clinical considerations to perform phage therapy clinical trials in patients with prothetic joint infection
Publications
- Septic Arthritis of Facet Joint in Children: A Systematic Review and a 10-year Consecutive Case Series.
- Editorial: Innovative Approaches in the Management of Bone and Joint Infection.
- Should all patients with a culture-negative periprosthetic joint infection be treated with antibiotics? : a multicentre observational study
- Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection
- Cost of off-label antibiotic therapy for bone and joint infections: a 6-year prospective monocentric observational cohort study in a referral centre for management of complex osteo-articular infections
- Safety of Tedizolid as Suppressive Antimicrobial Therapy for Patients With Complex Implant-Associated Bone and Joint Infection due to Multidrug-Resistant Gram-Positive Pathogens: Results From the TediSAT Cohort Study
- Novel strategies to diagnose prosthetic or native bone and joint infections
- Evaluation of intraosteoblastic activity of dalbavancin against Staphylococcus aureus in an ex vivo model of bone cell infection
- Recent progress toward the implementation of phage therapy in Western medicine
- Subcutaneous Antibiotic Therapy: The Why, How, Which Drugs and When
- The fused spine remains at risk of fracture after hardware removal: How should the implants be managed in case of late-onset infections?
- Arthroscopic « Debridement and Implant Retention » With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection
- Lysosomal alkalization to potentiate eradication of intra-osteoblastic Staphylococcus aureus in the bone and joint infection setting.
- Adherence to oral antibiotic therapy in patients with bone and joint infection: A pilot study
- Economic study of 2-stage exchange in patients with knee or hip prosthetic joint infection managed in a reference center in France: time to use innovative(s) intervention(s) at the time of reimplantation to reduce the risk of superinfection
- Management of prosthetic joint infections in France: a national audit to identify key situations requiring innovation and homogenization
- Pharmacokinetic/Pharmacodynamic Dosage Individualization of Suppressive Beta-Lactam Therapy Administered by Subcutaneous Route in Patients With Prosthetic Joint Infection
- Experience With the Use of the MicroDTTect Device for the Diagnosis of Low-Grade Chronic Prosthetic Joint Infections in a Routine Setting
- Impact on the Gut Microbiota of Intensive and Prolonged Antimicrobial Therapy in Patients With Bone and Joint Infection
- Antimicrobial activity of the new FabI inhibitor Afabicin desphosphono against intraosteoblastic Staphylococcus aureus
Ouvrages
Cas cliniques
- Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin‑rifampin treatment and complex reconstruction were needed for the cure
- Arthroscopic « Debridement Antibiotics and Implant Retention » With Local Injection of Personalized Phage Therapy to Salvage a Relapsing Pseudomonas Aeruginosa Prosthetic Knee Infection
Formation continue et webinaires
- Thérapie Phagique, Où en sommes nous ?
- Bone and joint infection Workshop
- Utilisation clinique de bactériophages
- French Periprosthetic infection Network Referral Reference Centers for the management of BJI
- Phagothérapie : une réponse à l’antibiorésistance ?
- Fagoterapia en el tratamiento de las infecciones causadas por Staphylococcus aureus ¿qué evidencia tenemos? Phage therapy in the treatment of infections caused by Staphylococcus aureus what evidence do we have?
- Phage therapy experience in France in the field of Bone and Joint Infection
- Problème difficile et ISO : Exemple des infections complexes en chirurgie orthopédique et leurs prises en charges multidisciplinaires
- LES PHAGES DANS LES IOA De l’historique aux indications pertinentes
Posters
- CEFTAROLINE AND CEFTOBIPROLE: REAL LIFE OFF LABEL USE IN PATIENTS WITH BJI OF THESE TWO BETALACTAMS ACTIVE AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCI
- IMPLEMENTATION OF A PHAGE THERAPY CENTER IN FRANCE DEDICATED TO COMPLEX BONE AND JOINT INFECTION: 4-YEAR EXPERIENCE OF MULTIDISCIPLINARITY AND MULTISTEP INTERACTIONS
- Coût des antibiothérapies hors AMM dans les infections ostéo-articulaires : Etude prospective observationnelle sur 6 ans dans un Centre de Référence pour la prise en charge des IOA complexes (CRIOAc)
- Projet PHAGEinLYON – Traitement par phagothérapie des infections ostéo-articulaires à staphylocoques: caractérisation de dix-sept bactériophages anti-Staphylococcus
- Mise en place d’un centre de phagothérapie en France dédié aux infections ostéo-articulaires complexes : 4 ans d’expérience de multidisciplinarité et d’interactions multi-étapes
- Conception et construction d’un bâtiment dédié aux maladies infectieuses et tropicales : huit années de travail concerté pour obtenir une structure innovante et modulable en fonction du risque épidémique
- Safety of tedizolid as suppressive antimicrobial therapy for patients with complex implant-associated bone and joint infection due to multidrug-resistant Gram-positive pathogens: results from the TediSAT cohort study
- Implementation of a phage therapy center in France dedicated to complex bone and joint infection: 4-year experience of multidisciplinarity and multistep interactions
- Impact on the gut microbiota of intensive and prolonged antimicrobial therapy in patients with bone and joint infection
- Results of a collaboration between a CRPV and an infectious disease care service
- Isolation and characterization of a novel Jumbo phage active against the emerging ST307 carbapenemase-producing K. pneumoniae clone
- Targeting coagulase negative staphylococci causing prosthetic infections with bacteriophages: can we use polyvalent anti Staphylococcus phages ?
- Phage discovery: isolation and characterization of seventeen novel anti-Staphylococcus aureus bacteriophages
DES et DESC de Maladies Infectieuses
Diplôme Inter-Universitaire
2020
Publications
- Septic Arthritis of Facet Joint in Children: A Systematic Review and a 10-year Consecutive Case Series
- Population pharmacokinetics of daptomycin in patients with bone and joint infection: minimal effect of rifampicin co-administration and confirmation of a sex difference
- Antibiotics in Bone Cements Used for Prosthesis Fixation: An Efficient Way to Prevent Staphylococcus aureus and Staphylococcus epidermidis Prosthetic Joint Infection
- Bone and Joint Infection Involving Corynebacterium spp.: From Clinical Features to Pathophysiological Pathways
- Outpatient Subcutaneous Antimicrobial Therapy (OSCAT) as a Measure to Improve the Quality and Efficiency of Healthcare Delivery for Patients With Serious Bacterial Infections
- Epidemiology of complex bone and joint infections in France using a national registry: The CRIOAc network
- Tolerance of Prolonged Oral Tedizolid for Prosthetic Joint Infections: Results of a Multicentre Prospective Study
- Anemia before reimplantation surgery : An overlooked modifiable risk factor of septic revision knee arthroplasty failure
- Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection
- Computerized registry as a potential tool for surveillance and management of complex bone and joint infections in France: French registry of complex bone and joint infections.
- Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach
- Plasma Cell Infiltration on Histopathological Samples of Chronic Bone and Joint Infections due to Cutibacterium acnes: A series of 21 Cases
- Hematogenous osteomyelitis in childhood can relapse many years later into adulthood
- Tolerance and Microbiological Efficacy of Cefepime or piperacillin/tazobactam in Combination With Vancomycin as Empirical Antimicrobial Therapy of Prosthetic Joint Infection: A Propensity-Matched Cohort Study
- Phagothérapie pour les patients présentant une infection ostéoarticulaire : historique, fondements, faisabilité et perspectives en France
- Phage therapy in bone and joint infection: history, scientific basis, feasibility and perspectives in France.
- Efficacy of Bacteriophages in a Staphylococcus aureus Nondiabetic or Diabetic Foot Infection Murine Model
- Evaluation of the Activity of a Combination of Three Bacteriophages Alone or in Association with Antibiotics on Staphylococcus aureus Embedded in Biofilm or Internalized in Osteoblasts
- Antibiofilm and intraosteoblastic activities of rifamycins against Staphylococcus aureus: promising in vitro profile of rifabutin
Diplôme Inter-Universitaire
- Antibiothérapie locale, phagothérapie
- Infections ostéoarticulaires, bactériophages et thérapie phagique : histoire et perspectives
- Dossiers Phagotherapie
- Les infections ostéo-articulaires (IOA) en 2020
Posters
- Utilité du dithiothréitol pour diagnostiquer les infections sur prothèses ostéo articulaires
- Personalized production and administration of bacteriophages: lessons learned from a unique European academic collaboration to treat a patient with pandrug-resistant spinal P. aeruginosa infection
- Intravenous administration of personalized cocktail of bacteriophages as salvage therapy in combination with ceftazidime/avibactam in patients with relapsing P. aeruginosa bacteremia associated with intravascular implants: Lesson to be learned from two cases
- Ultrasound-guided local administration of personalized cocktail of bacteriophages followed by suppressive antibiotherapy as salvage therapy in patients with relapsing total femur prosthetic joint infection (PJI)
- Arthroscopic Debridement Antibiotic And Implant Retention (DAIR) with local administration of Exebacase (Lysin CF-301) (LysinDAIR) followed by suppressive tedizolid as salvage therapy in elderly patients for relapsing multidrug-resistant Staphylococcus epidermidis prosthetic knee infection
Formation continue et webinaires
- Actualité du CRIOAc network et du comité scientifique des CRIOAc
- Bactériophage et infection de prothèse : le concept émergent du « Phago-DAIR »
- Nouvelles approches dans le traitement des Infections ostéo-articulaires
- Medical innovations to maintain the function in patients with PJI
- How to organize multidisciplinary management of the patient without a dedicated Bone Infection Unit (BIU)
Communications orales
- Optimisation du patient pour prévenir les infections de prothèse
- Osteomyelitis following mandibular reconstruction with free fibula flap : a cohort study of an emerging and complex bone and joint infection
- Actualités sur l’antibiothérapie et ses alternatives dans le traitement des IOA
- BIOTECHNOLOGY AND INFECTION PREVENTION
- Personalized medicine for bone and joint infection
- Comité Scientifique des CRIOAc
- Prise en charge des IOA complexes à l’ère des Bacilles à Gram négatif MDR
- Innovations et prise en charge des infections ostéoarticulaires
Thèses
- OTITES EXTERNES NECROSANTES, EPIDEMIOLOGIE FACTEURS DE RISQUE DE RECHUTE
- HISTOIRE DE LA PHAGOTHERAPIE A LYON
DES et DESC de Maladies Infectieuses
Cas cliniques
2019
Posters
- Tolerance and microbiological efficacy cefepim or piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of PJI
- Denosumab related osteonecrosis of the jaw: an emergent and potentially complex bone and joint infection
- Comparison of tolerance and microbiological efficacy of cefepim and piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of prosthetic joint infection: a propensity-matched cohort study
- Infections ostéo-articulaire à S. aureus : activité intra-ostéoblastique et anti-biofilm des rifamycines
- L’alcalinisation phagolysosomale dans le traitement des infections ostéo-articulairesà Staphylococcus aureus
- Comparaison de deux modèles pharmacocinétiques pour le suivi thérapeutique de la daptomycine
- Rôle du médecin anesthésiste dans la prise en charge des reprises septiques d’arthroplasties de genou
- Whole metagenome analysis with metagWGS
- Evaluation de l’efficacité d’un assemblage de trois bactériophages anti staphylococcus contre les bactéries au sein du biofilm ou internalisées dans les ostéoblastes
- Effets anti-biofilm prophylactiques de ciments osseux chargés d’antibiotiques contre Staphylococcus aureus et Staphylococcus epidermidis
- Assessment of drug adherence to oral antibacterial therapy in bone and joint infections: a pilot study
- Implementation and validation of a pharmacokinetic model for Bayesian therapeutic drug monitoring of daptomycin in patients with bone and joint infection
- Observance au traitement antibiotique par voie orale dans les infections ostéo-articulaires : étude pilote
- Pharmacocinétique de la daptomycine dans les infections ostéo-articulaires : intérêt du suivi thérapeutique pharmacologique et de l’individualisation posologique
- Economic study of medico-surgical strategies in patients with chronic knee or hip prosthetic joint infection
- Purified personalized bacteriophages as part of salvage therapy in patients with complex BJI: A 2-year experience in a reference center in France
- Impact on the gut microbiota of the prolonged antimicrobial therapy in patients with bone and joint infection (BJI): results from the OSIRIS prospective study in France
- Pseudomonas aeruginosa implant-associated Bone and Joint Infections : Experience in a Regional Reference Center in France
- Prophylactic anti-biofilm effects of antibiotic-loaded bone cements against Staphylococcus aureus and Staphylococcus epidermidis
- Evaluation of the efficacy of an assembly of three bacteriophages compared or associated to antibiotics on Staphylococcus aureus embedded in biofilms or internalised in osteoblasts
- Purified personalized bacteriophages as part of salvage therapy in patients with complex BJI: A 2-year experience in a reference center in France
- Denosumab related osteonecrosis of the jaw: an emergent and potentially complex bone and joint infection
Cas cliniques
Publications
- The CRIOAc healthcare network in France: A nationwide Health Ministry program to improve the management of bone and joint infection
- Subcutaneous suppressive antibiotic therapy for bone and joint infections: safety and outcome in a cohort of 10 patients
- Subcutaneous teicoplanin in staphylococcal bone and joint infections
- Pubic osteomyelitis: Epidemiology and factors associated with treatment failure
- Interaction Between Staphylococcal Biofilm and Bone: How Does the Presence of Biofilm Promote Prosthesis Loosening?
- Evaluation of the ability of linezolid and tedizolid to eradicate intraosteoblastic and biofilm-embedded Staphylococcus aureus in the bone and joint infection setting
- Efficacy of bacteriophages in a S. aureus non-diabetic or diabetic foot infection murine model
- Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study
Communications orales
- Phage therapy in patients with complex bone and joint infection
- Infections ostéo-articulaires sur matériel à Pseudomonas aeruginosa: expérience d’un centre de référence français
- Critères de complexité: quand faut-il confier son patient à un CRIOAc?
- Les CRIOAc: 10 ans d’expérience – Particularités anti-infectieuses Pour maintenir la fonction
- Outpatient Parenteral Antimicrobial Therapy : Lyon Experience
- Phage therapy to treat complex bone and joint infections in industrialized countries
2018
Publications
- Innovations et prise en charge des infections ostéoarticulaires : Des thérapies anti-infectieuses pour maintenir la fonction !
- Cefoxitin: Interesting Perspectives on a Neglected Intravenous Beta-lactam
- Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?
- Non-compliance with IDSA guidelines for patients presenting with methicillin-susceptible Staphylococcus aureus prosthetic joint infection is a risk factor for treatment failure
- Association between biofilm formation phenotype and clonal lineage in Staphylococcus aureus strains from bone and joint infections
- Prospective Cohort Study of the Tolerability of Prosthetic Joint Infection Empirical Antimicrobial Therapy
- Innovations for the treatment of a complex bone and joint infection due to XDR Pseudomonas aeruginosa including local application of a selected cocktail of bacteriophages
- Prolonged Cefoxitin Infusion Using Mobile Elastomeric Infusors In Outpatients With Bone And Joint Infection
- Erysipelas or cellulitis with a prosthetic joint in situ
- Outpatient parenteral antibiotic therapy: Evaluation of practices and limits of use in rural areas in France
- Population pharmacokinetics and probability of target attainment of ertapenem administered by subcutaneous or intravenous route in patients with bone and joint infection
- Pressure ulcer-related pelvic osteomyelitis: evaluation of a two-stage surgical strategy (debridement, negative pressure therapy and flap coverage) with prolonged antimicrobial therapy
- Salvage Debridement, Antibiotics and Implant Retention (« DAIR ») With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient With Relapsing Staphylococcus aureus Prosthetic-Joint Infection?
- Relevance of Modified Debridement-Irrigation, Antibiotic Therapy and Implant Retention Protocol for the Management of Surgical Site Infections: A Series of 1694 Instrumented Spinal Surgery.
Formation continue et webinaires
- Concept de traitements antibiotiques suppressifs – quand et comment ?
- Phagothérapie au cours des IOA : retour d’expérience sur les 3 cas traités aux HCL
- Organisation et activités des Centres de Référence des IOA complexes (CRIOAc) en AuRA
DES et DESC de Maladies Infectieuses
Thèses
- Implant-associated P. aeruginosa bone and joint infections : experience in a regional reference center in France
- Étude pilote sur l’observance des antibiotiques administrés par voie orale dans les infections ostéo-articulaires
- Augmentation du risque d’insuffisance rénale aigue lors de l’utilisation concomitante de vancomycine et piperacilline tazobactam : analyse de la base nationale de pharmacovigilance
Communications orales
- Révision pour infection Les « nouveaux » modes d’administration d’antibiothérapie locorégionale
- Révision pour infection : CRIOAc / Données nationales / Expérience LYSKS
- Révision pour infection : Pertinence des examens complémentaires lors d’une suspicion d’infection (Biologie)
- Révision pour infection : Les « nouveaux » modes d’administration d’antibiothérapie locorégionale
- PTG douloureuse : Qu’attendre des examens complémentaires ?
- Antibiothérapie probabiliste pour un sepsis grave sur matériel orthopédique : Ce (n’)est (pas) une loterie !
- Innovation in the clinical management of patients with complex BJI : Experience at the Lyon CRIOAc infection reference center
Diplôme Inter-Universitaire
- Présentation du Diplôme Inter-Universitaire Infections Ostéo-Articulaires et du Réseau des Centres de Référence des IOA (CRIOAc network)
- Interêt des bacteriophages et des lysines de bacteriophages au cours des infections ostéoarticulaires
- Innovation dans l’antibiothérapie locale
- Antibiothérapie hors AMM/non conventionnelle
- Concept de traitements antibiotiques suspensifs : quand et comment ?
- Impact de l’antibiothérapie prescrite au cours des IOA sur le microbiote intestinal
- Place de la recherche clinique dans le réseau des CRIOAc
Posters
- Interventional Study of Bone and Joint Infections related gut Dysbiosis (OSIRIS study): first results of a prospective multicenter trial
- Activité de nouvelles molécules anti-staphylococciques sur la persistance intra-ostéoblastique
- Infection de prothèse et changement en 1 temps : prétraitement par antibiothérapie ciblée chez des patients à risque
- Capacité du linézolide et du tédizolide à éradiquer Staphylococcus aureus en intracellulaire et sous forme de biofilm au cours du traitement des infections ostéo-articulaires
- Traitement des infections ostéo-articulaires à S. aureus : activité intra-ostéoblastiques des rifamycines et impact sur l’émergence intracellulaire de small colony variants
- Evaluation de l’utilisation de la céfoxitine en association en administration parentérale continue dans le traitement des infections ostéo-articulaires
- Infections chroniques sur prothèses articulaires (IPA) à Cutibacterium acnes diagnostiquées par PCR spécifique : une étude descriptive de 6 patients
- Salvage ‘DAIR’ (debridement, antibiotics and implant retention) with local injection of a selected mix of bacteriophages in an elderly patient with relapsing S. aureus prosthetic-joint infection
- Infections ostéo-articulaires : activité intra-ostéoblastique des rifamycines et oxazolidinones
- Staphylococcal acute post-operative prosthetic joint infection (PJI) treated with ‘DAIR’ (debridement and implant retention) and impact of rifampin: a retrospective cohort study in France
Cas cliniques
- Pott’s disease associated with large and multiple abscesses in a 30-year-old migrant from Chad
- Correction of Linezolid-Induced Myelotoxicity After Switch to Tedizolid in a Patient Requiring Suppressive Antimicrobial Therapy for Multidrug-Resistant Staphylococcus epidermidis Prosthetic-Joint Infection
- Chronic and severe prosthetic joint infection complicated by amyloid A amyloidosis with renal and bladder impairment
2017
Formation continue et webinaires
Thèses
Posters
- Selection and local application of a cocktail of bacteriophages in addition with local colistin therapy and off-label use of ceftolozane/tazobactam for the treatment of a complex bone and joint infection due to multidrug-resistant P. aeruginosa
- Cost of off-label antibiotic therapy in bone and joint infection (BJI) : prospective 2-year study in a complex BJI reference center
- Microbiological epidemiology in patients experiencing microbiological or clinical failure following reimplantation after a 2-stage exchange strategy for hip or knee prosthetic joint infection (PJI)
- Pressure ulcer-related pelvic osteomyelitis : Evaluation of a two-stage surgical strategy (debridement, negative pressure therapy and flap coverage) with prolonged antimicrobial therapy
- Microbiological epidemiology depending on time to occurrence of prosthetic joint infection (PJI) : impact on the empirical antimicrobial strategies
- Pubic osteomyelitis (PO) : Epidemiology and factors associated with management failure in two French Reference Centers
- Corynebacterium bone and joint infection (BJI): A retrospective cohort from a BJI reference center
- Subcutaneous Suppressive Antibiotic Therapy for Bone and Joints Infections: Safety and Outcome in a Cohort of 10 Patients
Cas cliniques
- Ethmoiditis with subperiosteal and retro-ocular abscesses due to Aeromonas sobria in a 16-year-old boy exposed to the Ardèche river
- Implant-associated ESBL- Klebsiella pneumonia producing small colony variant bone and joint infection in a healthy 40-year-old man
- Gentamicin-vancomycin-colistin local antibiotherapy in a cement spacer in a 54-year-old haemophilic patient with relapsing plurimicrobial severe prosthetic joint infection
- Intercalary diaphyseal endoprosthetic reconstruction for tibial septic non-union in an elderly patient: A case report
Publications
- Mechanisms of drug-drug interaction between rifampicin and fusidic acid
- Salvage therapy for complex bone and joint infections with ceftaroline: a multicentre, observational study
- Intraosteoblastic activity of daptomycin in combination with oxacillin and ceftaroline against MSSA and MRSA
- Clinical metagenomics of bone and joint infections: a proof of concept study
- Use of ceftolozane/tazobactam as salvage therapy for infections due to extensively drug-resistant Pseudomonas aeruginosa
- The not-so-good prognosis of streptococcal periprosthetic joint infection managed by implant retention: the results of a large multicenter study
- Prolonged suppressive antibiotic therapy for prosthetic joint infection in the elderly: a national multicentre cohort study
2016
Formation continue et webinaires
- Une antibiothérapie de 6 semaines est-elle adaptée à toutes les IOA ?
- Le « CRIOAc network » : Activité, nouveautés et perspectives
- Prise en charge des IOA suite à des traumatismes balistiques
- Ciments orthopédiques : avec ou sans antibiotique ?
Posters
- Investigation of the ability to be internalized in osteoblasts as a pathophysiological mechanism involved in Staphylococcus non-aureus bone and joint infection
- Pharmacokinetics of Ertapenem Administered by Intravenous or Subcutaneous Route in Patients with Bone and Joint Infections: Population and Monte Carlo simulation study
Communications orales
- Centre de Référence des Infections Ostéo-articulaires complexes (CRIOAc) : Structuration du soin et de la recherche aux HCL
- Anti-staphylococcal antibiotics: the new ones and the future ones…
Publications
- Infections ostéo-articulaires complexes : Le rôle des antibiotiques locaux
- Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis
- Adaptive processes of Staphylococcus aureus isolates during the progression from acute to chronic bone and joint infections in patients
- Diffuse Escherichia coli gaseous abscesses
- Pristinamycin in the treatment of MSSA bone and joint infection
- Teicoplanin-based antimicrobial therapy in Staphylococcus aureus bone and joint infection: tolerance, efficacy and experience with subcutaneous administration
- Daptomycin > 6 mg/kg/day as salvage therapy in patients with complex bone and joint infection: cohort study in a regional reference center
- Pharmacokinetic Variability of Daptomycin during Prolonged Therapy for Bone and Joint Infections
- Pathophysiological Mechanisms of Staphylococcus Non-aureus Bone and Joint Infection: Interspecies Homogeneity and Specific Behavior of S. pseudintermedius
Cas cliniques
- Disappearance of FDG uptake on PET scan after antimicrobial therapy could help for the diagnosis of Coxiella burnetii spondylodiscitis
- Three-step sequential management for knee arthroplasty after severe ballistic injury: Two cases
- Mycobacterium bovis prosthetic joint infection
- Chronic tibial pandiaphysitis with Brodie abscess due to Salmonella saprophyticus in a 29-year-old healthy man
Thèses
- Présentation clinique et épidémiologie des infections ostéo-articulaires pubiennes : étude de cohorte rétrospective au sein de deux CRIOAc
- Ostéomyélites hématogènes récidivantes a l’âge adulte
2015
Formation continue et webinaires
- Traitement des IOAc à Gram-négatif multirésistants : quelles options ?
- CRIOAc : Actualités (retour DGOS) et perspectives
Posters
- Autologous Bone Flap infection Following Craniectiomy: Clinical Experience in a Referral Center
- Antibiothérapie suppressive (ABS) dans les infections de prothèses ostéo-articulaires (IPOA) chez le patient âgé
- Evidence of adaptative processes of Staphylococcus aureus isolates in the course of chronic bone and joint infections in patients
- Management of P. acnes bone and joint infection in a regional reference centre in France
- Periprosthetic knee infection due to Pasteurella multocida: the cat was guilty!
Communications orales
- Pénétration intracellulaire des antibiotiques : Implications pour une stratégie anti-microbienne locale dans la prévention et le traitement des infections de prothèse
- ISO après instrumentation rachidienne : aspects médicaux
Cas cliniques
- Reactivation of Clostridium tertium bone infection 30 years after the Iran-Iraq war
- Post-traumatic chronic bone and joint infection caused by Butyricimonas spp, and treated with high doses of ertapenem administered subcutaneously in a 30-year-old obese man
- Chronic enterococcal spinal implant infection 6 years after instrumentation of a severe scoliosis in a 22-year-old woman
- A 22-year-old woman with right lumpy jaw syndrome and fistula
- Daptomycin-induced eosinophilic pneumonia
- Metallosis-associated prosthetic joint infection
Publications
- Delta-toxin production deficiency in Staphylococcus aureus: a diagnostic marker of bone and joint infection chronicity linked with osteoblast invasion and biofilm formation
- Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis
- Dual impact of live Staphylococcus aureus on the osteoclast lineage, leading to increased bone resorption
Thèses
2014
Communications orales
- Atelier interactif : Accidents graves aux antibiotiques
- Ostéites du volet crânien après craniectomie : cohorte rétrospective dans un Centre de Référence des IOA complexes
Publications
- Management strategies of prosthetic joint infections of the hip
- Rapid detection of Staphylococcus aureus and methicillin resistance in bone and joint infection samples: evaluation of the GeneXpert MRSA/SA SSTI assay
- Determinants of methicillin-susceptible Staphylococcus aureus native bone and joint infection treatment failure: a retrospective cohort study.
- Staphylococcus aureus-Related Diabetic Osteomyelitis: Medical or Surgical Management? A French and Spanish Retrospective Cohort
- Antimicrobial-related Severe Adverse Events During Treatment of Bone and Joint Infection Due to Methicillin-Susceptible Staphylococcus Aureus
- Methicillin-susceptible Staphylococcus Aureus Clonal Complex 398: High Prevalence and Geographical Heterogeneity in Bone and Joint Infection and Nasal Carriage
- Activation of NK cells in patients with chronic bone and joint infection due to staphylococci expressing or Not the small colony variant phenotype.
- Actinomycosis : etiology, clinical features, diagnosis, treatment and management
- Risk factors, diagnosis and management of bone flap osteomyelitis following craniectomy
Cas cliniques
Thèses
- Prise en charge et devenir des infections ostéo-articulaires à Propionibacterium acnes : étude rétrospective de cohorte au sein des hospices civils de Lyon
- Physiopathologie des infections ostéo-articulaires à Staphylococcus aureus
- Infections ostéo-articulaires à Staphylococcus aureus et Staphylococcus epidermidis : épidémiologie clinique et moléculaire, corrélation entre expression clinique et interaction staphylocoques – ostéoblastes
2013
Thèses
- Effets secondaires de l’antibiothérapie et pronostic des infections ostéo-articulaires à Staphylococcus aureus sensible à la meticilline: cohorte rétrospective monocentrique
- Internalisation et survie intracellulaire de S. aureus dans les ostéoblastes : rôle physiopathologique au cours de l’infection osseuse et impact des antibiotiques